Presentación No. 152

Presentación CITA 2009

This editorial is an introduction of the special issue composed with the best papers in e-learning of CITA2009 (Congreso Iberoamericano de Telemática). This congress was organized in Gijón/Xixón, Asturies, España, in May of 2009. The two selected papers are related with different matters of elearning, such as learning objects and system architecture. In this editorial we introduce CITA 2009 and...

Presentación De La Asignatura

Comments on «Carcinoma de tiroides incidental versus no incidental: presentación clínica, tratamiento quirúrgico y pronóstico».

Background and objective: Thyroid cancer may be clinically evident as a tumor mass in the neck or as a histopathological incidental finding after thyroid surgery for an apparent benign condition. Our objective was to assess the differences in clinical signs, surgical management, and course between incidental and clinically diagnosed thyroid tumors. Methods: A retrospective study was conducted o...

Dmd053017 141..152

Ticlopidine is a first-generation thienopyridine antiplatelet drug that prevents adenosine 59-diphosphate (ADP)-induced platelet aggregation. We identified the enzymes responsible for the two-step metabolic bioactivation of ticlopidine in human liver microsomes and plasma. Formation of 2-oxo-ticlopidine, an intermediate metabolite, was NADPH dependent and cytochrome P450 (CYP) 1A2, 2B6, 2C19, a...

Op-molb140259 144..152

Protein tyrosine phosphorylation is a key regulatory modification in metazoans, and the corresponding kinase enzymes have diversified dramatically. This diversification is correlated with a genome-wide reduction in protein tyrosine content, and it was recently suggested that this reduction was driven by selection to avoid promiscuous phosphorylation that might be deleterious. We tested three pr...